General Information:

Id: 9,686 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Mammalia
article
Reference: Jesus ICG et al.(2018) Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes Am. J. Physiol. 314: C702-C711 [PMID: 29443552]

Interaction Information:

Comment The renin-angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. Alamandine and its receptor MrgD are components of RAS. In this study goal was twofold: 1) to unravel the signaling molecules activated by the alamandine/MrgD axis in cardiomyocytes; and 2) to evaluate the ability of this axis to prevent angiotensin II (ANG II)-induced hypertrophy. Confirming previous data, ANG-(1–7) induced a significant rise in NO.
Formal Description
Interaction-ID: 102331

gene/protein

Angiotensin (1-7)

increases_quantity of

drug/chemical compound

NO

in ventricular cardiomyocytes