General Information:

Id: 924 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
Tg2576 mouse model
primary neurons
article
Reference: Rezai-Zadeh K et al.(2005) Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice J. Neurosci. 25: 8807-8814 [PMID: 16177050]

Interaction Information:

Comment EGCG markedly promotes cleavage of the alpha-C-terminal fragment of APP and elevates the N-terminal APP cleavage product, soluble APP-alpha. These cleavage events are associated with elevated alpha-secretase activity and enhanced hydrolysis of tumor necrosis factor alpha-converting enzyme, a primary candidate alpha-secretase.
Formal Description
Interaction-ID: 5661

drug/chemical compound

Epigallocatechin 3-gallate

increases_processing of

gene/protein

APP

at alpha-C-terminal fragment of APP
Drugbank entries Show/Hide entries for APP