General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment Exposure to a high-fat diet and diet-induced obesity lead to a chronic inflammatory reaction, which is believed to be critical for the development of glucose intolerance and insulin resistance. The expression of IL-6 and TNF-alpha, two major proinflammatory cytokines, was significantly enhanced in livers of wild-type mice on a chronic high-fat diet (HFD). Transgenic mice on HFD, however, still exhibited low levels of inflammatory markers, comparable to those seen in wild-type and transgenic mice on chow diet.
Formal Description
Interaction-ID: 5384


high-fat diet

increases_expression of



in liver
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