General Information:

Id: 878 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
HER14 cell, NIH3T3 fibroblasts stably transfected with human EGF receptor cDNA
Reference: Fallon L et al.(2006) A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling Nat. Cell Biol. 8: 834-842 [PMID: 16862145]

Interaction Information:

Comment EGF stimulation allows the formation of a transient EGF-dependent, parkin-Eps15-EGFR protein complex, implicating parkin, for the first time, in a growth-factor signaling and trafficking pathway.
Formal Description
Interaction-ID: 5172



affects_activity of