General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
SirBACO: SirT1 bacterial artificial chromosome overexpressor
article
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment Metabolic characterization of SirBACO mice was carried out on a standard diet. Serum metabolite levels, including insulin and glucose, were normal, as was the response to intraperitoneal glucose or insulin challenge tests. However, an about 30% increase in plasma adiponectin levels was detected.
Formal Description
Interaction-ID: 5182

gene/protein

SIRT1

increases_quantity of

gene/protein

ADIPOQ

in blood; on standard diet, if SIRT1 is overexpressed
Comment Whereas high fat feeding was associated with a modest decrease in plasma adiponectin levels in wild-type mice, in SirBACO mice a 30%-40% rise was observed, suggesting that the ability to prevent hyperglycemia is due to increased adiponectin synthesis/secretion, independent of differences in body fat mass.
Formal Description
Interaction-ID: 5188

gene/protein

SIRT1

increases_quantity of

gene/protein

ADIPOQ

in blood; on high-fat diet, if SIRT1 is overexpressed
Comment To identify the source of increased adiponectin levels, adiponectin mRNA was measured in white adipose tissue (WAT) from mice fed either standard or high-fat diets and a similar increase was observed.
Formal Description
Interaction-ID: 5194

gene/protein

SIRT1

increases_expression of

gene/protein

ADIPOQ

in white adipose tissue; on standard diet, on high-fat diet, if SIRT1 is overexpressed