General Information:

Id: 8,563 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Rattus norvegicus
article
Reference: Tallino S et al.(2015) Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease J. Nutr. Biochem. 26: 996-1006 [PMID: 26033743]

Interaction Information:

Comment Transcripts associated with MetS included increased gene expression of the angiotensin-1-converting enzyme (Ace) in high-sucrose and low-copper diets. In the high sucrose diet, increased lipocalin 2 (Lcn2) and decreased cytochrome p450 family 8 subfamily B1 (Cyp8b1) gene expression were observed in both high-sucrose and low copper high-sucrose diets, while all three diets led to increased transcript levels of laminin alpha 1 (Lama1) and the six-transmembrane epithelial antigen of the prostate 2 (Steap2) metalloreductase.
Formal Description
Interaction-ID: 88222

environment

low-copper diet

increases_expression of

gene/protein

ACE

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