General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J Endocrinol 204: 93-104 [PMID: 19770177]

Interaction Information:

Comment Exposure of insulin-sensitive tissues (in particular liver and skeletal muscle) to excess nonesterified fatty acids (FA) and circulating triglycerides (triacylglycerol, TAG) induces insulin resistance that can be corrected by the administration of PPAR-alpha activators by actions to promote removal of intracellular lipid through tissue FA oxidation.
Formal Description
Interaction-ID: 4787



decreases_activity of


Insulin resistance

in liver, in skeletal muscle; if induced by excess nonesterified fatty acids and circulating triacylglycerol
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