General Information:

Id: 792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Koren J 3rd et al.(2009) Chaperone signalling complexes in Alzheimers disease J. Cell. Mol. Med. 13: 619-630 [PMID: 19449461]

Interaction Information:

Comment The ER chaperone BiP/Grp78 (the ER isoform of Hsp70) associates with APP, likely indicating that Grp94 (the ER isoform of Hsp90) can regulate APP as well.
Formal Description
Interaction-ID: 4623

gene/protein

HSPA5

interacts (colocalizes) with

gene/protein

APP

in endoplasmic reticulum
Drugbank entries Show/Hide entries for HSPA5 or APP
Comment CHIP also interacts with APP.
Formal Description
Interaction-ID: 4628

gene/protein

STUB1

interacts (colocalizes) with

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment HSF1 induces the APP gene during stress.
Formal Description
Interaction-ID: 4681

gene/protein

HSF1

increases_expression of

gene/protein

APP

during stress
Drugbank entries Show/Hide entries for APP