General Information:

Id: 787 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
Reference: Finck BN et al.(2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway Cell Metab 4: 199-210 [PMID: 16950137]

Interaction Information:

Comment Lipin 1 induced the expression of nuclear receptor PPAR-alpha (Ppara) and many of its target genes involved in fatty acid uptake and utilization. Lipin 1 interacts with the Ppara promoter in a region known to be transcriptionally-activated by PGC-1alpha and nuclear receptors.
Formal Description
Interaction-ID: 4410



increases_expression of



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