CIDeRGeneral Information:
| Id: | 7,559 (click here to show other Interactions for entry) |
| Diseases: |
Metabolic
Phenylketonuria - [OMIM] |
| Mammalia | |
| review | |
| Reference: | Schuck PF et al.(2015) Phenylketonuria Pathophysiology: on the Role of Metabolic Alterations Aging Dis 6: 390-399 [PMID: 26425393] |
Interaction Information:
| Comment | Phenylalanine is hydroxylated to tyrosine by PAH, found in liver and kidney. Alternatively phenylalanine is converted to phenylpyruvic acid (PPA), which is catalyzed by the enzyme phenylalanine (histidine) transaminase (EC 2.6.1.58), found mainly in liver. This reaction is activated by the substrate phenylalanine and might therefore become more relevant if phenylalanine levels are high. The third pathway is the decarboxylation of phenylalanine to phenylethylamine by phenylalanine decarboxylase (EC 4.1.1.53). |
|
Formal Description Interaction-ID: 74813 |
drug/chemical compound decreases_quantity of drug/chemical compound |