General Information:

Id: 7,412 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
Reference: Riedel BC et al.(2016) Age, APOE and sex: Triad of risk of Alzheimers disease J. Steroid Biochem. Mol. Biol. 160: 134-147 [PMID: 26969397]

Interaction Information:

Comment Age, apolipoprotein E4 (APOE4) and chromosomal sex are well-established risk factors for late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least one APOE-E4 allele.
Formal Description
Interaction-ID: 72681

gene/protein mutant

APOE (isoform E4)

increases_activity of