General Information:

Id: 7,255 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Phillips MC(2014) Apolipoprotein E isoforms and lipoprotein metabolism IUBMB Life 66: 616-623 [PMID: 25328986]

Interaction Information:

Comment ApoE4 binds better than apoE3 to the surface of very low density lipoprotein (VLDL) particles and impairs their lipolytic processing in the circulation so that apoE4 is associated with a more pro-atherogenic lipoprotein-cholesterol distribution (higher VLDL-cholesterol / high density lipoprotein-cholesterol ratio).
Formal Description
Interaction-ID: 71403

gene/protein mutant

APOE (isoform E4)

increases_activity of


increased pro-atherogenic lipoprotein-cholesterol distribution