General Information:

Id: 7,250 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
HEK293 cells; ES-cell-derived human neurons
Reference: Huang YA et al.(2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 168: 427-441.e21 [PMID: 28111074]

Interaction Information:

Comment ApoE2, ApoE3, and ApoE4 differentially stimulate Abeta40 and Abeta42 secretion by human neurons cultured on MEFs (murine embryonic fibroblasts) with an ApoE4 > ApoE3 > ApoE2 potency rank order.
Formal Description
Interaction-ID: 71315

gene/protein mutant

APOE (isoform E4)

increases_activity of


Amyloid beta peptide (40) secretion

in human neurons cultured on MEFs ; compared to ApoE3 and ApoE2