General Information:

Id: 667 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Celsi F et al.(2009) Mitochondria, calcium and cell death: a deadly triad in neurodegeneration Biochim. Biophys. Acta 1787: 335-344 [PMID: 19268425]

Interaction Information:

Comment APP can interact with the mitochondrial TIM/TOM protein import complex. The presence of an acidic domain within APP sequence may be responsible for an incomplete mitochondrial translocation that, in turn, inhibited the entry of nuclear-encoded mitochondrial proteins.
Formal Description
Interaction-ID: 3601

gene/protein

APP

interacts (colocalizes) with

complex/PPI

TIM complex, mitochondrial

in mitochondrion
Drugbank entries Show/Hide entries for APP