General Information:

Id: 613 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
article
Reference: Chen Y et al.(2009) Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimers amyloid peptides via up-regulating BACE1 transcription Proc Natl Acad Sci U S A 106: 3907-3912 [PMID: 19237574]

Interaction Information:

Comment The increased A-beta production caused by metformin was not due to increased APP expression, because the total APP level was unaltered.
Formal Description
Interaction-ID: 3266

drug/chemical compound

Metformin

NOT affects_expression of

gene/protein

APP

Drugbank entries Show/Hide entries for Metformin or APP