General Information:

Id: 580 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
brain
article
Reference: Phiel CJ et al.(2003) GSK-3alpha regulates production of Alzheimers disease amyloid-beta peptides Nature 423: 435-439 [PMID: 12761548]

Interaction Information:

Comment Lithium, a GSK-3 inhibitor, block the production of amyloid beta peptides by interfering with APP cleavage at the gamma-secretase step.
Formal Description
Interaction-ID: 3103

drug/chemical compound

Lithium

affects_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for Lithium or APP
Comment GSK-3 regulates APP processing. Selective reduction of GSK-3A protein expression decreased amyloid beta40 peptide (Ab40) and amyloid beta42 peptide (Ab42) levels.
Formal Description
Interaction-ID: 3140

gene/protein

GSK3A

affects_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment GSK-3 regulates APP processing.
Formal Description
Interaction-ID: 3141

gene/protein

GSK3B

affects_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for GSK3B or APP