General Information:

Id: 5,787 (click here to show other Interactions for entry)
Diseases: Lung disease
Pulmonary fibrosis, idiopathic - [OMIM]
Mus musculus
bleomycin model of murine fibrosis, Lrp5 -/- mice
article
Reference: Lam AP et al.(2014) Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis Am. J. Respir. Crit. Care Med. 190: 185-195 [PMID: 24921217]

Interaction Information:

Comment Elevated TGF-beta levels are involved in the development of pulmonary fibrosis.
Formal Description
Interaction-ID: 54624

gene/protein

TGFB1

increases_activity of

phenotype

pulmonary fibrosis

Drugbank entries Show/Hide entries for TGFB1
Comment Lrp5 loss is associated with reduced TGFbeta production. Lrp5 loss attenuates fibrosis through limiting TGFbeta abundance in both alveolar epithelial and immune cells with kinetics that follow the progression of this injury model.
Formal Description
Interaction-ID: 54625

gene/protein

LRP5

increases_quantity of

gene/protein

TGFB1

in alveolar type 2 cells and leukocytes
Drugbank entries Show/Hide entries for TGFB1