General Information:

Id: 574 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Zhou S et al.(2007) Regulation of gamma-secretase activity in Alzheimers disease. Biochemistry 46: 2553-2563 [PMID: 17298085]

Interaction Information:

Comment APP, a type I transmembrane (TM) glycoprotein believed to play a role in neuroprotection, synaptic transmission, signal transduction, and axonal transport, is a target of apha-, beta-, and gamma-secretase processing.
Formal Description
Interaction-ID: 3016

complex/PPI

Gamma-secretase complex

affects_processing of

gene/protein

APP

Drugbank entries Show/Hide entries for APP