General Information:

Id: 569 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000089 blood
article
Reference: Boyt AA et al.(2000) The effect of insulin and glucose on the plasma concentration of Alzheimers amyloid precursor protein. Neuroscience 95: 727-734 [PMID: 10670439]

Interaction Information:

Comment Glucose and insulin affect the plasma concentration of Alzheimer's disease amyloid precursor protein. Due to the strong direct relationship between glucose and insulin, determining which initiates the change in APP levels may be moot.
Formal Description
Interaction-ID: 2966

drug/chemical compound

Glucose

affects_quantity of

gene/protein

APP

in plasma
Drugbank entries Show/Hide entries for APP
Comment Glucose and insulin affect the plasma concentration of Alzheimer's disease amyloid precursor protein. Due to the strong direct relationship between glucose and insulin, determining which initiates the change in APP levels may be moot.
Formal Description
Interaction-ID: 2967

complex/PPI

Insulin

affects_quantity of

gene/protein

APP

in plasma
Drugbank entries Show/Hide entries for APP
Comment There is an ApoE genotype effect on the decrease in plasma APP concentration.
Formal Description
Interaction-ID: 2986

gene/protein

APOE

decreases_quantity of

gene/protein

APP

in plasma
Drugbank entries Show/Hide entries for APOE or APP