General Information:

Id: 560 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
Reference: Olzmann JA et al.(2007) Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J. Cell Biol. 178: 1025-1038 [PMID: 17846173]

Interaction Information:

Comment Even at extremely high levels of overexpression, parkin was unable to promote degradation of L166P mutant or wild-type DJ-1.
Formal Description
Interaction-ID: 2913



NOT decreases_quantity of

gene/protein mutant


via ubiquitin-mediated proteasomal degradation