General Information:

Id: 517 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell; BTO:0000567 HeLa cell; BTO:0002393 N-27 cell (rat cell line transfected with human PINK1)
Reference: Vives-Bauza C et al.(2010) PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl. Acad. Sci. U.S.A. 107: 378-383 [PMID: 19966284]

Interaction Information:

Comment PINK1 and Parkin seems to be key elements of the mitochondrial trafficking machinery responsible for delivering defective mitochondria to the autophagy system.
Formal Description
Interaction-ID: 45616



increases_activity of

together with Pink1