General Information:

Id: 505
Diseases: Alzheimer disease - [OMIM]
Mus musculus
article
Reference: Leem JY et al.(2002) Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J. Biol. Chem. 277 [PMID: 11943765]

Interaction Information:

Comment Presenilins (PS1 and PS2) facilitate the final step in Abeta production, the intramembranous beta-secretase cleavage of amyloid precursor protein.
Formal Description
Interaction-ID: 2509

gene/protein

PSEN1

increases_quantity of

gene/protein

Amyloid beta peptide

Comment Presenilins (PS1 and PS2) facilitate the final step in Abeta production, the intramembranous beta-secretase cleavage of amyloid precursor protein.
Formal Description
Interaction-ID: 2510

gene/protein

PSEN2

increases_quantity of

gene/protein

Amyloid beta peptide

Comment PS1 is required for maturation and cell surface accumulation of nicastrin.
Formal Description
Interaction-ID: 2511

gene/protein

PSEN1

affects_processing of

gene/protein

NCSTN

PSEN1 acts as member of gamma-secretase complex (CorumID: 466)
Comment Presenilin is required for proper glycosylation of nicastrin.
Formal Description
Interaction-ID: 2517

gene/protein

PSEN1

affects_glycosylation of

gene/protein

NCSTN

Comment Membrane fractionation studies show co-localization of PS1 fragments with mature nicastrin.
Formal Description
Interaction-ID: 2519

gene/protein

PSEN1

interacts (colocalizes) with

gene/protein

NCSTN

Comment Nicastrin is an integral component of the multimeric gamma-secretase complex.
Formal Description
Interaction-ID: 14080

gene/protein

NCSTN

is_part_of

complex/PPI

Gamma-secretase complex

Comment Proteolytic processing of amyloid precursor protein generates beta-amyloid (Abeta) peptides that are deposited in senile plaques in brains of aged individuals and patients with Alzheimer's disease.
Formal Description
Interaction-ID: 14082

gene/protein

Amyloid beta peptide

increases_quantity of

Comment Proteolytic processing of amyloid precursor protein generates beta-amyloid (Abeta) peptides that are deposited in senile plaques in brains of aged individuals and patients with Alzheimer's disease.
Formal Description
Interaction-ID: 14083

gene/protein

APP

increases_quantity of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for APP