General Information:

Id: 499
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000567 HeLa cell
article
Reference: Narendra D et al.(2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy J Cell Biol 183: 795-803 [PMID: 19029340]

Interaction Information:

Comment Endogenous Parkin was predominately located in the cytosol. However, in some of the cells, colocalization was observed between Parkin and a subset of the mitochondria, which were small and fragmented.
Formal Description
Interaction-ID: 2418

gene/protein

PRKN

is localized in

cellular component

cytoplasm

Comment Endogenous Parkin was predominately located in the cytosol. However, in some of the cells, colocalization was observed between Parkin and a subset of the mitochondria, which were small and fragmented.
Formal Description
Interaction-ID: 2430

gene/protein

PRKN

is localized in

cellular component

mitochondrion

Comment Mitochondrial depolarization, induced by treatment of cells with the uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP), causes the redistribution of Parkin from the cytosol to the mitochondria.
Formal Description
Interaction-ID: 2431

drug/chemical compound

CCCP

increases_transport of

gene/protein

PRKN

into mitochondria
Comment Mitochondrial depolarization, induced by treatment of cells with the uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP), causes the redistribution of Parkin from the cytosol to the mitochondria.
Formal Description
Interaction-ID: 2432

increases_transport of

gene/protein

PRKN

into mitochondria
Comment Parkin selectively induces mitophagy, which suggests that Parkin could maintain fidelity of mitochondria by activating the autophagy of dysfunctional mitochondria.
Formal Description
Interaction-ID: 2433

gene/protein

PRKN

increases_activity of

Comment Parkin colocalizes with LC3 after CCCP treatment but not before.
Formal Description
Interaction-ID: 2434

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

MAP1LC3A

after CCCP treatment
Comment Mitochondrial depolarization, induced by treatment of cells with the uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP), causes the redistribution of Parkin from the cytosol to the mitochondria.
Formal Description
Interaction-ID: 2436

drug/chemical compound

CCCP

increases_activity of

Comment Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential induced by CCCP treatment.
Formal Description
Interaction-ID: 2556

increases_transport of

gene/protein

PRKN

into mitochondria
Comment Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential induced by CCCP treatment.
Formal Description
Interaction-ID: 2557

drug/chemical compound

CCCP

increases_activity of

Comment Parkin selectively induces mitophagy, which suggests that Parkin could maintain fidelity of mitochondria by activating the autophagy of dysfunctional mitochondria.
Formal Description
Interaction-ID: 9829

gene/protein

PRKN

decreases_activity of

by promoting autophagic degradation of mitochondria
Comment Parkin selectively induces mitophagy, which suggests that Parkin could maintain fidelity of mitochondria by activating the autophagy of dysfunctional mitochondria.
Formal Description
Interaction-ID: 9835

increases_activity of