General Information:

Id: 491
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Yamauchi T et al.(2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8: 1288-1295 [PMID: 12368907]

Interaction Information:

Comment Phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length adiponectin (Ad) in skeletal muscle and only with full-length Ad in the liver.
Formal Description
Interaction-ID: 2323

gene/protein

ADIPOQ

increases_activity of

complex/PPI

AMPK

in skeletal muscle; globular and full length adiponectin
Comment Phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length adiponectin (Ad) in skeletal muscle and only with full-length Ad in the liver.
Formal Description
Interaction-ID: 2325

gene/protein

ADIPOQ

increases_activity of

complex/PPI

AMPK

in liver; only full length adiponectin
Comment Phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length adiponectin (Ad) in skeletal muscle and only with full-length Ad in the liver.
Formal Description
Interaction-ID: 2326

gene/protein

ADIPOQ

increases_phosphorylation of

gene/protein

AMPK alpha chain

in skeletal muscle; globular and full length adiponectin
Comment Phosphorylation and activation of the 5'-AMP-activated protein kinase (AMPK) are stimulated with globular and full-length adiponectin (Ad) in skeletal muscle and only with full-length Ad in the liver.
Formal Description
Interaction-ID: 2327

gene/protein

ADIPOQ

increases_phosphorylation of

gene/protein

AMPK alpha chain

in liver; only full length adiponectin
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2328

gene/protein

ADIPOQ

increases_phosphorylation of

gene/protein

ACAC

in muscle
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2329

gene/protein

ADIPOQ

increases_activity of

in muscle
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2330

gene/protein

ADIPOQ

increases_activity of

process

glucose import

in muscle
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2331

gene/protein

ADIPOQ

increases_activity of

in muscle
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2332

gene/protein

ADIPOQ

increases_phosphorylation of

gene/protein

ACACB

in liver
Drugbank entries Show/Hide entries for ACACB
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2334

gene/protein

ADIPOQ

decreases_expression of

gene/protein

PCK1

in liver
Drugbank entries Show/Hide entries for PCK1
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2335

gene/protein

ADIPOQ

decreases_expression of

gene/protein

G6PC

in liver
Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2336

gene/protein

ADIPOQ

decreases_quantity of

drug/chemical compound

Glucose

Comment The adipocyte-derived hormone, adiponectin, activates AMPK and thereby directly regulates glucose metabolism and insulin sensitivity in vitro and in vivo.
Formal Description
Interaction-ID: 2337

gene/protein

ADIPOQ

affects_activity of

Comment The adipocyte-derived hormone, adiponectin, activates AMPK and thereby directly regulates glucose metabolism and insulin sensitivity in vitro and in vivo.
Formal Description
Interaction-ID: 12759

gene/protein

ADIPOQ

affects_activity of