General Information:

Id: 491 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Yamauchi T et al.(2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8: 1288-1295 [PMID: 12368907]

Interaction Information:

Comment In parallel with its activation of AMPK, adiponectin stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver (PEPCK and G6Pase), and reduction of glucose levels in vivo.
Formal Description
Interaction-ID: 2331



increases_activity of

in muscle