General Information:

Id: 488 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Ye JM et al.(2002) Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver. Endocrinology 143: 4527-4535 [PMID: 12446579]

Interaction Information:

Comment Plasma adiponectin was increased 2-fold in Pioglitazone-treated rats and was negatively correlated with hepatic glucose output and liver long-chain acyl-coenzyme A.
Formal Description
Interaction-ID: 2301

drug/chemical compound

Pioglitazone

increases_quantity of

gene/protein

ADIPOQ

in blood
Drugbank entries Show/Hide entries for Pioglitazone
Comment Thiazolidinediones can protect against lipid-induced insulin resistance with a significant component (mainly liver) of the protective effect not requiring lipid lowering. This may be related to chronic elevation of adiponectin by thiazolidinediones.
Formal Description
Interaction-ID: 12757

drug/chemical compound

Thiazolidinedione

increases_quantity of

gene/protein

ADIPOQ