General Information:

Id: 450 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
CCS/G93A-SOD1 dual transgenic mouse, transfected with human CCS and SOD1G93A
Reference: Son M et al.(2007) Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology Proc. Natl. Acad. Sci. U.S.A. 104: 6072-6077 [PMID: 17389365]

Interaction Information:

Comment CCS overexpression alters the cytosolic/mitochondrial distribution of G93A-SOD1. Mutant SOD1 is enriched within the mitochondria of CCS/G93A-SOD1 dual mice compared with G93A-SOD1 mice.
Formal Description
Interaction-ID: 1996



increases_quantity of

gene/protein mutant


in mitochondria; if CCS is overexpressed