General Information:

Id: 405
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell
article
Reference: Ren Y et al.(2003) Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation J. Neurosci. 8: 3316-3324 [PMID: 12716939]

Interaction Information:

Comment Parkin binds to alpha and beta tubulin.
Formal Description
Interaction-ID: 1738

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

TUBB

Drugbank entries Show/Hide entries for TUBB
Comment Parkin binds to alpha and beta tubulin.
Formal Description
Interaction-ID: 1739

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

TUBA

Comment Parkin enhances ubiquitination of alpha and beta tubulin.
Formal Description
Interaction-ID: 1741

gene/protein

PRKN

increases_ubiquitination/sumoylation of

gene/protein

TUBB

Drugbank entries Show/Hide entries for TUBB
Comment Parkin enhances ubiquitination of alpha and beta tubulin.
Formal Description
Interaction-ID: 1742

gene/protein

PRKN

increases_ubiquitination/sumoylation of

gene/protein

TUBA

Comment Only wild-type parkin causes a significant increase in the ubiquitination of alpha- and beta-tubulins. Parkin mutants found in PD patients do not ubiquitinate alpha- and beta-tubulin.
Formal Description
Interaction-ID: 1753

gene/protein mutant

PARK2-p.K161N

NOT increases_ubiquitination/sumoylation of

gene/protein

TUBB

Drugbank entries Show/Hide entries for TUBB
Comment Only wild-type parkin causes a significant increase in the ubiquitination of alpha- and beta-tubulins. Parkin mutants found in PD patients do not ubiquitinate alpha- and beta-tubulin.
Formal Description
Interaction-ID: 1754

gene/protein mutant

PARK2-p.K161N

NOT increases_ubiquitination/sumoylation of

gene/protein

TUBA

Comment Only wild-type parkin causes a significant increase in the ubiquitination of alpha- and beta-tubulins. Parkin mutants found in PD patients do not ubiquitinate alpha- and beta-tubulin.
Formal Description
Interaction-ID: 1755

gene/protein mutant

PARK2-p.T240R

NOT increases_ubiquitination/sumoylation of

gene/protein

TUBB

Drugbank entries Show/Hide entries for TUBB
Comment Only wild-type parkin causes a significant increase in the ubiquitination of alpha- and beta-tubulins. Parkin mutants found in PD patients do not ubiquitinate alpha- and beta-tubulin.
Formal Description
Interaction-ID: 1756

gene/protein mutant

PARK2-p.T240R

NOT increases_ubiquitination/sumoylation of

gene/protein

TUBA

Comment Only wild-type parkin causes a significant increase in the ubiquitination of alpha- and beta-tubulins. Parkin mutants found in PD patients do not ubiquitinate alpha- and beta-tubulin.
Formal Description
Interaction-ID: 1757

gene/protein mutant

PARK2-p.C431F

NOT increases_ubiquitination/sumoylation of

gene/protein

TUBB

Drugbank entries Show/Hide entries for TUBB
Comment Only wild-type parkin causes a significant increase in the ubiquitination of alpha- and beta-tubulins. Parkin mutants found in PD patients do not ubiquitinate alpha- and beta-tubulin.
Formal Description
Interaction-ID: 1758

gene/protein mutant

PARK2-p.C431F

NOT increases_ubiquitination/sumoylation of

gene/protein

TUBA

Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1759

gene/protein

PRKN

decreases_quantity of

gene/protein

TUBB

via ubiquitin-mediated proteasomal degradation
Drugbank entries Show/Hide entries for TUBB
Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1760

gene/protein

PRKN

decreases_quantity of

gene/protein

TUBA

via ubiquitin-mediated proteasomal degradation
Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1761

gene/protein mutant

PARK2-p.K161N

NOT decreases_quantity of

gene/protein

TUBB

via ubiquitin-mediated proteasomal degradation
Drugbank entries Show/Hide entries for TUBB
Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1762

gene/protein mutant

PARK2-p.K161N

NOT decreases_quantity of

gene/protein

TUBA

via ubiquitin-mediated proteasomal degradation
Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1763

gene/protein mutant

PARK2-p.T240R

NOT decreases_quantity of

gene/protein

TUBB

via ubiquitin-mediated proteasomal degradation
Drugbank entries Show/Hide entries for TUBB
Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1764

gene/protein mutant

PARK2-p.T240R

NOT decreases_quantity of

gene/protein

TUBA

via ubiquitin-mediated proteasomal degradation
Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1765

gene/protein mutant

PARK2-p.C431F

NOT decreases_quantity of

gene/protein

TUBB

via ubiquitin-mediated proteasomal degradation
Drugbank entries Show/Hide entries for TUBB
Comment Parkin, but not its mutants linked to PD, accelerates degradation of alpha- and beta-tubulins.
Formal Description
Interaction-ID: 1766

gene/protein mutant

PARK2-p.C431F

NOT decreases_quantity of

gene/protein

TUBA

via ubiquitin-mediated proteasomal degradation