General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment BzATP was found as the most effective agonist in switching hSOD1-G93A microglia from resting to activated state, in terms of cellular morphology, synthesis of TNF-alpha and COX-2 (but not IL-1-beta) proinflammatory factors, as well as in inducing consequent detrimental effects on neurons.
Formal Description
Interaction-ID: 1768

gene/protein mutant


increases_activity of

in SOD1G93A transgenic mice