General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment The experiments showed a down-regulation of ATP-hydrolyzing activities in mutant SOD1 microglia. Immortalized nontransgenic microglia degraded extracellular ATP more efficiently than hSOD1-G93A cells.
Formal Description
Interaction-ID: 1728

gene/protein mutant


decreases_activity of

in immortalized microglia