General Information:

Id: 404 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0000078 microglia
Reference: D'Ambrosi N et al.(2009) The proinflammatory action of microglial P2 receptors is enhanced in SOD1 models for amyotrophic lateral sclerosis J. Immunol. 183: 4648-4656 [PMID: 19734218]

Interaction Information:

Comment The induction of the ALS phenotype through hSOD1-G93A expression has a direct impact on purinergic signaling in microglia. ATP can reach high levels in the extracellular space as a consequence of release from both dying or abnormally functioning cells. It acts as a neuron-to-microglia alarm signal, through cell surface P2 receptors widely distributed throughout the CNS.
Formal Description
Interaction-ID: 13520

gene/protein mutant


affects_activity of

in immortalized and primary microglia