General Information:

Id: 3,892 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Ringseis R et al.(2012) Regulation of Genes Involved in Carnitine Homeostasis by PPARalpha across Different Species (Rat, Mouse, Pig, Cattle, Chicken, and Human) PPAR Res 2012 [PMID: 23150726]

Interaction Information:

Comment It is well established that PPARalpha activators exert distinct species-specific actions. In rodents, like mice and rats, administration of PPARalpha activators leads to a marked peroxisomal enzyme induction, peroxisome proliferation, and even hepatocarcinogenesis. In contrast, PPARalpha activators cannot induce peroxisome proliferation and hepatocarcinogenesis and the induction of peroxisomal metabolism pathways is much less pronounced in human hepatocytes and livers from nonhuman primates. This distinct response of the peroxisomes to PPARalpha activators is responsible for the classification of different species into proliferating (mice, rats) and nonproliferating ones (humans, monkeys, guinea pigs). Several factors are considered to account for the marked difference in the response to PPARalpha activators between different species: expression level of PPARalpha, degree of conservation and functionality of the PPRE in the regulatory region of target genes, and lack or overexpression of transcriptional coregulators.
Formal Description
Interaction-ID: 39384



affects_activity of

in rodents
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