General Information:

Id: 386 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
mouse transduced with adenoviruses expressing either murine mtGPAT (GPAM) or a catalytically inactive variant of the enzyme
Reference: Linden D et al.(2006) Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation FASEB J. 20: 434-443 [PMID: 16507761]

Interaction Information:

Comment mtGPAT overexpression did not affect mRNA levels of PPAR-alpha or its downstream target genes: acyl-CoA oxidase (ACO), medium-chain acyl-CoA dehydrogenase (MCAD) or CPT-1.
Formal Description
Interaction-ID: 1719


Mitochondrial GPAT

NOT affects_expression of



if mitochondrial GPAT is overexpressed in liver
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