General Information:

Id: 381 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cell
Reference: Edbauer D et al.(2002) Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc. Natl. Acad. Sci. U.S.A. 99: 8666-8671 [PMID: 12048259]

Interaction Information:

Comment Amyloid beta-peptide (Abeta) is generated by the consecutive cuts of two membrane-bound proteases: beta-secretase and gamma-secretase. Beta-secretase cuts at the N-terminus of the Abeta domain, whereas gamma-secretase mediates the C-terminal cut.
Formal Description
Interaction-ID: 1564


Gamma-secretase complex

increases_processing of



Drugbank entries Show/Hide entries for APP