General Information:

Id: 3,761 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Azizi G and Mirshafiey A(2012) The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis Immunopharmacol Immunotoxicol 34: 881-895 [PMID: 22970774]

Interaction Information:

Comment Some data report that TGF-beta1 and nuclear Smad7 and beta-catenin levels are markedly upregulate in cortical brain regions of the TgCRND8 mice, a mouse model of familial AD, and this high brain level of Abeta and TGF-beta1 have been implicated in the cognitive and cerebrovascular alterations of AD.
Formal Description
Interaction-ID: 37230

increases_expression of

gene/protein

TGFB1

in cortical brain regions; of the TgCRND8 mice, a mouse model of familial AD
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