General Information:

Id: 3,749 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Rattus norvegicus
male
Otsuka Long-Evans Tokushima Fatty (OLETF) rat
article
Reference: Ko GJ et al.(2008) Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats Nephrol. Dial. Transplant. 23: 2750-2760 [PMID: 18388116]

Interaction Information:

Comment In cDNA microarray analysis using renal cortical tissues, several inflammatory and profibrotic genes were significantly down-regulated by pioglitazone including NF-kappaB, CCL2, TGFbeta1, PAI-1 and VEGF.
Formal Description
Interaction-ID: 36468

drug/chemical compound

Pioglitazone

decreases_expression of

gene/protein

TGFB1

in kidney
Drugbank entries Show/Hide entries for Pioglitazone or TGFB1