General Information:

Id: 3,746 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
female
mouse model of unilateral ureteral obstruction (UUO)
article
Reference: Kawai T et al.(2009) PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta Lab. Invest. 89: 47-58 [PMID: 19002105]

Interaction Information:

Comment Transforming growth factor-beta1 (TGF-beta1) mRNA and TGF-beta1 type I receptor (TGF beta R-I) mRNA and protein expression were decreased in the group treated with troglitazone compared with the control group.
Formal Description
Interaction-ID: 36421

drug/chemical compound

Troglitazone

decreases_expression of

gene/protein

TGFB1

in kidney
Drugbank entries Show/Hide entries for Troglitazone or TGFB1