General Information:

Id: 3,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
PPARalpha-/- mouse
Reference: Makowski L et al.(2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation FASEB J. 23: 586-604 [PMID: 18945875]

Interaction Information:

Comment Also striking was the marked skeletal muscle accumulation of isovalerylcarnitine (C5), a byproduct of leucine catabolism. Whereas fasting did not alter C5 content in skeletal muscle of wild-type mice, this metabolite increased 5-fold in PPARalpha -/- animals. Pairwise correlation analysis revealed a strong positive relation between skeletal muscle C5 levels and plasma leucine/isoleucine, but only in PPARalpha -/- animals. Surprisingly, C5 levels were not elevated in the plasma of PPARalpha -/- mice, suggesting that tissue efflux of this specific metabolite might be limited for reasons that are yet unclear.
Formal Description
Interaction-ID: 32561



affects_quantity of

drug/chemical compound


in skeletal muscle
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