General Information:

Id: 3,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
PPARalpha-/- mouse
Reference: Makowski L et al.(2009) Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation FASEB J. 23: 586-604 [PMID: 18945875]

Interaction Information:

Comment Fasting glucose and ketone levels were lower, whereas plasma NEFAs were markedly elevated in PPARalpha -/- compared to PPARalpha+/+ mice. Plasma insulin levels and the insulin:glucose ratio in PPARalpha -/-mice trended lower in the fed state but was increased relative to wild-type mice in the fasted state. Thus, the absence of PPARalpha caused an inappropriate rise in insulin secretion during fasting-induced hypoglycemia.
Formal Description
Interaction-ID: 32511



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