General Information:

Id: 322
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cells (transfected)
article
Reference: Yu G et al.(2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing Nature 407: 48-54 [PMID: 10993067]

Interaction Information:

Comment Missense mutations in a conserved hydrophilic domain of nicastrin increase amyloid-beta42 and amyloid-beta40 peptide secretion. Deletions in this domain inhibit amyloid-beta production.
Formal Description
Interaction-ID: 1268

gene/protein mutant

NCSTN-mut

increases_quantity of

increased gamma-secretase cleavage by missense mutations in a conserved hydrophilic domain of nicastrin (NCSTN);
Comment Nicastrin binds carboxy-terminal derivatives of amyloid-beta precursor protein, and modulates the production of the amyloid-beta peptide (Ab) from these derivatives.
Formal Description
Interaction-ID: 1269

gene/protein

NCSTN

interacts (colocalizes) with

gene/protein

APP

Drugbank entries Show/Hide entries for APP
Comment Missense mutations in a conserved hydrophilic domain of nicastrin increase amyloid-beta42 and amyloid-beta40 peptide secretion. Deletions in this domain inhibit amyloid-beta production.
Formal Description
Interaction-ID: 1273

gene/protein mutant

NCSTN-del

decreases_quantity of

gene/protein

Amyloid beta peptide

decreased gamma-secretase cleavage by deletion mutations of NCSTN;
Comment Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction.
Formal Description
Interaction-ID: 1280

gene/protein

NCSTN

affects_activity of

Comment Immunoprecipitation studies in human brain and in transfected HEK293 cells confirm interactions between nicastrin and presenilin1 or presenilin2.
Formal Description
Interaction-ID: 1281

gene/protein

NCSTN

interacts (colocalizes) with

gene/protein

PSEN1

Comment Immunoprecipitation studies in human brain and in transfected HEK293 cells confirm interactions between nicastrin and presenilin1 or presenilin2.
Formal Description
Interaction-ID: 1283

gene/protein

NCSTN

interacts (colocalizes) with

gene/protein

PSEN2

Comment Calnexin not interacts with nicastrin.
Formal Description
Interaction-ID: 1287

gene/protein

CANX

NOT interacts (colocalizes) with

gene/protein

NCSTN

Drugbank entries Show/Hide entries for CANX
Comment Calnexin not interacts with presenilin 1.
Formal Description
Interaction-ID: 1289

gene/protein

CANX

NOT interacts (colocalizes) with

gene/protein

PSEN1

Drugbank entries Show/Hide entries for CANX
Comment The bAPP holoprotein (FL-bAPP) is physiologically processed by a two-step proteolytic pathway.
Formal Description
Interaction-ID: 1290

increases_activity of

gene/protein

APP

by a two-step proteolytic pathway
Drugbank entries Show/Hide entries for APP
Comment Missense mutations in a conserved hydrophilic domain of nicastrin increase amyloid-beta42 and amyloid-beta40 peptide secretion. Deletions in this domain inhibit amyloid-beta production.
Formal Description
Interaction-ID: 14054

gene/protein mutant

NCSTN-mut

increases_quantity of

increased gamma-secretase cleavage by missense mutations in a conserved hydrophilic domain of nicastrin (NCSTN);
Comment Nicastrin binds carboxy-terminal derivatives of amyloid-beta precursor protein, and modulates the production of the amyloid-beta peptide (Ab) from these derivatives.
Formal Description
Interaction-ID: 14059

gene/protein

NCSTN

affects_quantity of

gene/protein

Amyloid beta peptide