General Information:

Id: 3,191 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
postmortem cortical tissue (APOE4 and non-APOE4 carriers)
Reference: Conejero-Goldberg C et al.(2011) Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimers disease as based on APOE genotype Mol. Psychiatry 16: 836-847 [PMID: 20479757]

Interaction Information:

Comment CASP6 is involved in programmed cell death. It is strongly upregulated in the temporal cortex of the APOE4 group, while modestly downregulated in the primary somatosensory cortex of the APOE4 group. This may represent a response in the APOE4 group that confers susceptibility to AD pathology.
Formal Description
Interaction-ID: 118869

gene/protein mutant

APOE (isoform E4)

increases_expression of



in the temporal cortex of the APOE4 group; strongly upregulated