General Information:

Id: 3,064 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Reference: Ronnemaa E et al.(2008) Impaired insulin secretion increases the risk of Alzheimer disease Neurology 71: 1065-1071 [PMID: 18401020]

Interaction Information:

Comment The population-based Uppsala Longitudinal Study of Adult Men started 1970 when the 2,322 participants were 50 years old. A low insulin response at baseline was associated with a higher cumulative risk of Alzheimer disease (AD) also after adjustment for age, systolic blood pressure, body mass index, serum cholesterol, smoking, education level, and insulin resistance. This association was stronger in subjects without the APOE epsilon4 allele. Impaired glucose tolerance increased the risk of vascular dementia but not AD. Impaired insulin secretion, glucose intolerance, and estimates of insulin resistance were all associated with higher risk of any dementia and cognitive impairment.
Formal Description
Interaction-ID: 28099

gene/protein mutant

APOE (isoform E4)

increases_activity of