General Information:

Id: 2,842 (click here to show other Interactions for entry)
Diseases: Breast cancer - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Reference: Hadad S et al.(2011) Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res. Treat. 128: 783-794 [PMID: 21655990]

Interaction Information:

Comment By ingenuity pathway analysis, the tumour necrosis factor receptor 1 (TNFR1) signaling pathway was most affected by metformin: TGFB and MEKK were upregulated and cdc42 downregulated; mTOR and AMPK pathways were also affected. Gene set analysis additionally revealed that p53, BRCA1 and cell cycle pathways also had reduced expression following metformin.
Formal Description
Interaction-ID: 26199

drug/chemical compound


increases_expression of



Drugbank entries Show/Hide entries for Metformin or TGFB1