General Information:

Id: 2,266 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
SPP1 -/- mouse (OPN-/-)
Reference: Kiefer FW et al.(2011) Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diabetologia 54: 2132-2142 [PMID: 21562757]

Interaction Information:

Comment Hepatic mRNA expression of inflammatory Tnf and Tgfb1, known to be crucially involved in pathogenesis and progression of NAFLD was increased with HF in WT mice but significantly less in Opn-/- mice.
Formal Description
Interaction-ID: 19363


high-fat diet

increases_expression of



in liver
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