General Information:

Id: 2,266 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
SPP1 -/- mouse (OPN-/-)
article
Reference: Kiefer FW et al.(2011) Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diabetologia 54: 2132-2142 [PMID: 21562757]

Interaction Information:

Comment Hepatic mRNA expression of inflammatory Tnf and Tgfb1, known to be crucially involved in pathogenesis and progression of NAFLD was increased with HF in WT mice but significantly less in Opn-/- mice.
Formal Description
Interaction-ID: 19363

environment

high-fat diet

increases_expression of

gene/protein

TGFB1

in liver
Drugbank entries Show/Hide entries for TGFB1