General Information:

Id: 2,077
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Skidgel RA and Erdos EG(1985) Novel activity of human angiotensin I converting enzyme: release of the NH2- and COOH-terminal tripeptides from the luteinizing hormone-releasing hormone. Proc. Natl. Acad. Sci. U.S.A. 82: 1025-1029 [PMID: 2983326]

Interaction Information:

Comment LH-RH, which also contains a blocked COOH-terminal amino acid, was cleaved by human ACE at the bond between Leu-7 and Arg-8 to release the COOH-terminal tripeptide, Arg-Pro-Gly-NH2, similar to the results found with substance P.
Formal Description
Interaction-ID: 16743

gene/protein

ACE

decreases_quantity of

gene/protein

Gonadoliberin-1

Drugbank entries Show/Hide entries for ACE
Comment LH-RH, which also contains a blocked COOH-terminal amino acid, was cleaved by human ACE at the bond between Leu-7 and Arg-8 to release the COOH-terminal tripeptide, Arg-Pro-Gly-NH2, similar to the results found with substance P.
Formal Description
Interaction-ID: 16744

gene/protein

ACE

increases_quantity of

drug/chemical compound

Arg-Pro-Gly-NH2

Drugbank entries Show/Hide entries for ACE
Comment ACE also hydrolyzed the bond between Trp-3 and Ser-4 to release the NH2-terminal tripeptide, Glu-His-Trp. This finding was quite unexpected as ACE usually cleaves dipeptides from the COOH terminus of peptide substrates with free COOH-terminal amino acids and has not been shown before to cleave at the NH2 terminus.
Formal Description
Interaction-ID: 16745

gene/protein

ACE

increases_quantity of

drug/chemical compound

Glu-His-Trp

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Comment The heptapeptide Glu-His-Trp-Ser-Tyr-GIy-Leu, which results from the C-terminal cleavage of LH-RH by ACE is further processed by ACE to release Gly-Leu, Ser-Tyr, and Glu-His-Trp.
Formal Description
Interaction-ID: 16746

gene/protein

ACE

increases_quantity of

drug/chemical compound

Gly-Leu

Drugbank entries Show/Hide entries for ACE
Comment The heptapeptide Glu-His-Trp-Ser-Tyr-GIy-Leu, which results from the C-terminal cleavage of LH-RH by ACE is further processed by ACE to release Gly-Leu, Ser-Tyr, and Glu-His-Trp.
Formal Description
Interaction-ID: 16747

gene/protein

ACE

increases_quantity of

drug/chemical compound

Ser-Tyr

Drugbank entries Show/Hide entries for ACE