General Information:

Id: 2,076 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Primary human dermal microvascular EC
article
Reference: Scholzen TE et al.(2007) Terminating the stress: peripheral peptidolysis of proopiomelanocortin-derived regulatory hormones by the dermal microvascular endothelial cell extracellular peptidases neprilysin and angiotensin-converting enzyme. Endocrinology 148: 2793-2805 [PMID: 17363457]

Interaction Information:

Comment POMC peptides ACTH and alpha-MSH are substrates for the Zn metalloproteases NEP and ACE, which have an important role in controlling cutaneous inflammation.
Formal Description
Interaction-ID: 16739

gene/protein

ACE

decreases_quantity of

gene/protein

Alpha-MSH

Drugbank entries Show/Hide entries for ACE