General Information:

Id: 2,075 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Oryctolagus cuniculus
article
Reference: Dubreuil P et al.(1989) Novel activity of angiotensin-converting enzyme. Hydrolysis of cholecystokinin and gastrin analogues with release of the amidated C-terminal dipeptide. Biochem. J. 262: 125-130 [PMID: 2554881]

Interaction Information:

Comment ACE (angiotensin-converting enzyme; peptidyl dipeptidase A; EC 3.4.15.1), cleaves C-terminal dipeptides from active peptides containing a free C-terminus. The hydrolysis of cholecystokinin-8 [CCK-8; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2] and of various gastrin analogues by purified rabbit lung ACE was investigated. Although these peptides are amidated at their C-terminal end, they were metabolized by ACE to several peptide fragments. The initial and major site of hydrolysis was the penultimate peptide bond, which generated a major product, the C-terminal amidated dipeptide Asp-Phe-NH2.
Formal Description
Interaction-ID: 16735

gene/protein

ACE

decreases_quantity of

gene/protein

Cholecystokinin-8

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