General Information:

Id: 2,074
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Hayakari M et al.(1997) Kinetic evaluation of beta-neoendorphin hydrolysis by the somatic and testicular isozymes of human angiotensin-converting enzyme. Biochim. Biophys. Acta 1339: 31-38 [PMID: 9165097]

Interaction Information:

Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16725

gene/protein

ACE

decreases_quantity of

gene/protein

Beta-neoendorphin(1-9)

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16726

gene/protein

ACE

increases_quantity of

gene/protein

Beta-neoendorphin(1-7)

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16727

gene/protein

ACE

increases_quantity of

drug/chemical compound

Tyr-Pro

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16728

gene/protein

ACE

decreases_quantity of

gene/protein

Beta-neoendorphin(1-7)

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16729

gene/protein

ACE

increases_quantity of

gene/protein

Leu-enkephalin

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16730

gene/protein

ACE

increases_quantity of

drug/chemical compound

Arg-Lys

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16731

gene/protein

ACE

decreases_quantity of

gene/protein

Leu-enkephalin

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16732

gene/protein

ACE

increases_quantity of

drug/chemical compound

Tyr-Gly-Gly

Drugbank entries Show/Hide entries for ACE
Comment Angiotensin-converting enzyme (ACE) has both somatic and testicular isozymes, the former possessing two catalytically active domains, amino-terminal and carboxyl-terminal, while the latter has only the carboxyl-terminal one. Hydrolysis of beta-neoendorphin(1-9) by both the somatic and testicular isozymes (ACE-S and ACE-T) proceeds by the sequential removal of carboxyl-terminal dipeptides in three consecutive steps: beta-neoendorphin(1-9) is cleaved to beta-neoendorphin(1-7) plus Tyr-Pro, beta-neoendorphin(1-7) is cleaved to Leu-enkephalin plus Arg-Lys, Leu-enkephalin is cleaved to Tyr-Gly-Gly plus Phe-Leu.
Formal Description
Interaction-ID: 16733

gene/protein

ACE

increases_quantity of

drug/chemical compound

Phe-Leu

Drugbank entries Show/Hide entries for ACE