General Information:

Id: 2,072 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
ApoE4 mouse
article
Reference: Shenk JC et al.(2009) The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimers disease J. Neurol. Sci. 283: 199-206 [PMID: 19342064]

Interaction Information:

Comment Compared to WT mice, CBF (cerebral blood flow) was significantly lower in ApoE4 6-month and 12-month mice.
Formal Description
Interaction-ID: 16715

gene/protein mutant

APOE (isoform E4)

increases_activity of

in ApoE4 6-month and 12-month mice; compared to WT mouse
Comment Compared to WT mice, CBF (cerebral blood flow) was significantly lower in ApoE4 6-month and 12-month mice.
Formal Description
Interaction-ID: 16716

gene/protein mutant

APOE (isoform E4)

increases_activity of

in ApoE4 6-month and 12-month mice; compared to WT mouse
Comment ApoE4 reduces CBF gradually to create brain hypoperfusion when compared to WT and the differences in CBF are greatest as animals age from 6 weeks to 12 months.
Formal Description
Interaction-ID: 16717

gene/protein mutant

APOE (isoform E4)

increases_activity of

phenotype

brain hypoperfusion

in ApoE4 6-month and 12-month mice; compared to WT mouse
Comment The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse (a model of human Alzheimer disease) is shown.
Formal Description
Interaction-ID: 16719

gene/protein mutant

APOE (isoform E4)

increases_activity of

in APOE4 mice
Comment Microvessels from ApoE4 mice show the stress reaction of vascular endothelium.
Formal Description
Interaction-ID: 16751

gene/protein mutant

APOE (isoform E4)

increases_activity of

in APOE4 mouse microvessels
Comment Microvessels from ApoE4 mice show the stress reaction of vascular endothelium.
Formal Description
Interaction-ID: 16752

gene/protein mutant

APOE (isoform E4)

affects_activity of

tissue/cell line

vascular endothelium

in APOE4 mouse microvessels
Comment Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description
Interaction-ID: 38965

gene/protein mutant

APOE (isoform E4)

decreases_activity of

in APOE4 mice; if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
Comment Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description
Interaction-ID: 95893

gene/protein mutant

APOE (isoform E4)

increases_activity of

phenotype

cognitive impairment

in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
Comment Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description
Interaction-ID: 95894

drug/chemical compound

mitochondrial antioxidants

decreases_activity of

gene/protein mutant

APOE (isoform E4)

in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
Comment Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description
Interaction-ID: 95895

drug/chemical compound

Acetylcarnitine

decreases_activity of

gene/protein mutant

APOE (isoform E4)

in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid
Comment Spatial memory and temporal memory tests showed a trend in improving cognitive function in ApoE4 mice fed selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid.
Formal Description
Interaction-ID: 95896

drug/chemical compound

R-alpha-lipoic acid

decreases_activity of

gene/protein mutant

APOE (isoform E4)

in APOE4 mice; improved cognitive impairment if mice are fed with selective mitochondrial antioxidants acetyl-L-carnitine and R-alpha-lipoic acid