General Information:

Id: 2,056 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
review
Reference: Skidgel RA and Erdos EG(1987) The broad substrate specificity of human angiotensin I converting enzyme. Clin Exp Hypertens A 9: 243-259 [PMID: 2440624]

Interaction Information:

Comment Human ACE hydrolyzed substance P in vitro and released the protected C-terminal tripeptide (Gly-Leu-Met-NH2) and the C-terminal dipeptide at a 4:1 ratio. The hydrolysis was chloride dependent, and inhibited by captopril. When tested in vivo, the ACE inhibitor captopril potentiated the effect of substance P on salivation in the rat.
Formal Description
Interaction-ID: 16629

drug/chemical compound

Captopril

decreases_activity of

gene/protein

ACE

Drugbank entries Show/Hide entries for Captopril or ACE